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Weed Use and Memory Loss

Elephants May Never Forget, But Humans Aren't So Lucky. Especially if You Smoke Weed.

What are marijuana’s long-term effects on the brain?

Substantial evidence from animal research and a growing number of studies in humans indicate that marijuana exposure during development can cause long-term or possibly permanent adverse changes in the brain. Rats exposed to THC before birth, soon after birth, or during adolescence show notable problems with specific learning and memory tasks later in life. Cognitive impairments in adult rats exposed to THC during adolescence are associated with structural and functional changes in the hippocampus. Studies in rats also show that adolescent exposure to THC is associated with an altered reward system, increasing the likelihood that an animal will self-administer other drugs (e.g., heroin) when given an opportunity

Several studies, including two large longitudinal studies, suggest that marijuana use can cause functional impairment in cognitive abilities but that the degree and/or duration of the impairment depends on the age when a person began using and how much and how long he or she used.

Among nearly 4,000 young adults in the Coronary Artery Risk Development in Young Adults study tracked over a 25-year period until mid-adulthood, cumulative lifetime exposure to marijuana was associated with lower scores on a test of verbal memory but did not affect other cognitive abilities such as processing speed or executive function.

The effect was sizeable and significant even after eliminating those involved with current use and after adjusting for confounding factors such as demographic factors, other drug and alcohol use, and other psychiatric conditions such as depression.

A large longitudinal study in New Zealand found that persistent marijuana use disorder with frequent use starting in adolescence was associated with a loss of an average of 6 or up to 8 IQ points measured in mid-adulthood.43 Significantly, in that study, those who used marijuana heavily as teenagers and quit using as adults did not recover the lost IQ points. People who only began using marijuana heavily in adulthood did not lose IQ points. These results suggest that marijuana has its strongest long-term impact on young people whose brains are still busy building new connections and maturing in other ways. The endocannabinoid system is known to play an important role in the proper formation of synapses (the connections between neurons) during early brain development, and a similar role has been proposed for the refinement of neural connections during adolescence. If the long-term effects of marijuana use on cognitive functioning or IQ are upheld by future research, this may be one avenue by which marijuana use during adolescence produces its long-term effects.

Marijuana, Memory, and the Hippocampus

 

Distribution of cannabinoid receptors in the rat brain. Brain image reveals high levels (shown in orange and yellow) of cannabinoid receptors in many areas, including the cortex, hippocampus, cerebellum, and nucleus accumbens (ventral striatum).

Memory impairment from marijuana use occurs because THC alters how the hippocampus, a brain area responsible for memory formation, processes information. Most of the evidence supporting this assertion comes from animal studies. For example, rats exposed to THC in utero, soon after birth, or during adolescence, show notable problems with specific learning/memory tasks later in life. Moreover, cognitive impairment in adult rats is associated with structural and functional changes in the hippocampus from THC exposure during adolescence.

As people age, they lose neurons in the hippocampus, which decreases their ability to learn new information. Chronic THC exposure may hasten age-related loss of hippocampal neurons. In one study, rats exposed to THC every day for 8 months (approximately 30 percent of their lifespan) showed a level of nerve cell loss at 11 to 12 months of age that equaled that of unexposed animals twice their age.  https://www.drugabuse.gov/publications/research-reports/marijuana/what-are-marijuanas-long-term-effects-brain

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Nootropic: n, adj: dietary supplement that helps support certain brain functions, such as memory, mental speed, and focus.

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RenuFocus™ by quitters relief

RenuFocus™ Ingredients:

"Use the (ANALYSIS) button to read detailed Medical Analysis of every Ingredient in our supplements formula "

Ginkgo Biloba

According to the University of Maryland Medical Center (UMM), “Gingko is widely used in Europe for treating dementia.” Doctors started to use it because they thought it improved blood flow to the brain, but more recent studies indicate that it may protect nerve cells from damage in Alzheimer’s.

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Phosphatidylserine

Phosphatidylserine (fos-fuh-tie-dul-SER-een) is a dietary supplement that has received some interest as a potential treatment for Alzheimer’s disease and other memory problems. Several studies with phosphatidylserine indicate improved cognitive abilities and behaviors.

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N-Acetyl L-Carnitine HCl

Acetyl-L-carnitine is used for a variety of mental disorders including Alzheimer’s disease, age-related memory loss, late-life depression, thinking problems related to alcoholism, and thinking problems related to Lyme disease.

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St. Johns Wort

In this study we tested the hypothesis that St John’s wort (Hypericum perforatum) may counteract stress-induced memory impairment.

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L-Glutamine

L-glutamine can help improve alertness, concentration, focus, memory and mood, boost Human Growth Hormone and reduce anxiety

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Bacopa Leaf Extract

Brahmi (BACOPA) might increase certain brain chemicals that are involved in thinking, learning, and memory. Some research suggests that it might also protect brain cells from chemicals involved in Alzheimer’s disease.

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Vinpocetine

Vinpocetine might improve blood flow to the brain, it is used for enhancing memory and preventing Alzheimer’s disease and other conditions that harm learning, memory

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Huperzine - A

Huperzine A is thought to be beneficial for problems with memory, loss of mental abilities (dementia), and the muscular disorder myasthenia gravis because it causes an increase in the levels of acetylcholine. Acetylcholine is one of the chemicals that our nerves use to communicate in the brain, muscles, and other areas.

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RenuFocus™  – Nutritional Statement Label

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