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"Whether your preferred vice is pot or alcohol, gambling or Big Macs, it stands to reason that if you overdo it, you're going to damage yourself".

What are marijuana’s long-term effects on the brain?

Substantial evidence from animal research and a growing number of studies in humans indicate that marijuana exposure during development can cause long-term or possibly permanent adverse changes in the brain. Rats exposed to THC before birth, soon after birth, or during adolescence show notable problems with specific learning and memory tasks later in life. Cognitive impairments in adult rats exposed to THC during adolescence are associated with structural and functional changes in the hippocampus. Studies in rats also show that adolescent exposure to THC is associated with an altered reward system, increasing the likelihood that an animal will self-administer other drugs (e.g., heroin) when given an opportunity

Several studies, including two large longitudinal studies, suggest that marijuana use can cause functional impairment in cognitive abilities but that the degree and/or duration of the impairment depends on the age when a person began using and how much and how long he or she used.

Among nearly 4,000 young adults in the Coronary Artery Risk Development in Young Adults study tracked over a 25-year period until mid-adulthood, cumulative lifetime exposure to marijuana was associated with lower scores on a test of verbal memory but did not affect other cognitive abilities such as processing speed or executive function.

The effect was sizeable and significant even after eliminating those involved with current use and after adjusting for confounding factors such as demographic factors, other drug and alcohol use, and other psychiatric conditions such as depression.

A large longitudinal study in New Zealand found that persistent marijuana use disorder with frequent use starting in adolescence was associated with a loss of an average of 6 or up to 8 IQ points measured in mid-adulthood.43 Significantly, in that study, those who used marijuana heavily as teenagers and quit using as adults did not recover the lost IQ points. People who only began using marijuana heavily in adulthood did not lose IQ points. These results suggest that marijuana has its strongest long-term impact on young people whose brains are still busy building new connections and maturing in other ways. The endocannabinoid system is known to play an important role in the proper formation of synapses (the connections between neurons) during early brain development, and a similar role has been proposed for the refinement of neural connections during adolescence. If the long-term effects of marijuana use on cognitive functioning or IQ are upheld by future research, this may be one avenue by which marijuana use during adolescence produces its long-term effects.

 

Marijuana, Memory, and the Hippocampus

Distribution of cannabinoid receptors in the rat brain. Brain image reveals high levels (shown in orange and yellow) of cannabinoid receptors in many areas, including the cortex, hippocampus, cerebellum, and nucleus accumbens (ventral striatum).

Memory impairment from marijuana use occurs because THC alters how the hippocampus, a brain area responsible for memory formation, processes information. Most of the evidence supporting this assertion comes from animal studies. For example, rats exposed to THC in utero, soon after birth, or during adolescence, show notable problems with specific learning/memory tasks later in life. Moreover, cognitive impairment in adult rats is associated with structural and functional changes in the hippocampus from THC exposure during adolescence.

As people age, they lose neurons in the hippocampus, which decreases their ability to learn new information. Chronic THC exposure may hasten age-related loss of hippocampal neurons. In one study, rats exposed to THC every day for 8 months (approximately 30 percent of their lifespan) showed a level of nerve cell loss at 11 to 12 months of age that equaled that of unexposed animals twice their age.  https://www.drugabuse.gov/publications/research-reports/marijuana/what-are-marijuanas-long-term-effects-brain

 

RenuFocus™ It Works To Realize Your Potential 

How RenuFocus™ Works

Natural nootropics are proven in boosting the brain function while at the same time making the brain healthier. Nootropics act as a vasodilator against the small arteries and veins in the brain. Introduction of natural nootropics in the system will increase the blood circulation to the brain and at the same time provide the important nutrient and increase energy and oxygen flow to the brain.

In fact, the brain can only generate energy from burning the glucose, proving that neuron depends on the continuous supply of oxygen and nutrients. In contrast to most of other cells in the body, neuron cannot be reproduced and is irreplaceable. The neuron cells are persistently expending the converted energy to maintain the repair of the cell compartments.

The administration of nootropics will protect the brain from toxins and minimizing the effects of brain aging. Effects of natural nootropics in improving the brain function are also contributed through the stimulation of the new neuron cell. As incentive from the new neuronal cell, the activity of the brain is increased, enhancing the thinking and memory abilities, thus increasing neuroplasticity.

 

 

Supplemental Facts Label

Suggested Use: Take 1 Capsule Taken 1 to 2 times daily.
Preferably With Meals or As Advised by Your Healthcare Professional.

Ingredients

Ginkgo Biloba - 50mg

For Improved Thinking

Ginkgo Biloba is one of the most ancient seed plant, often referred to as a “living fossil.” This large tree may live over 1000 years and reach 40 m of height. Originally native to China, Gb is now cultivated worldwide. Extract from Gb leaves has been used in traditional Chinese medicine for centuries to treat circulatory disorders, asthma, tinnitus, vertigo, and cognitive problems.

 

Phosphatidylserine - 125mg

For Memory Loss Support

Phosphatidylserine is required for healthy nerve cell membranes and myelin. Aging of the human brain is associated with biochemical alterations and structural deterioration that impair neurotransmission. Exogenous PS (300-800 mg/d) is absorbed efficiently in humans, crosses the blood-brain barrier, and safely slows, halts, or reverses biochemical alterations and structural deterioration in nerve cells. It supports human cognitive functions, including the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories, the ability to retrieve memories, the ability to learn and recall information, the ability to focus attention and concentrate, the ability to reason and solve problems, language skills, and the ability to communicate. It also supports locomotor functions, especially rapid reactions and reflexes

N-Acetyl L-Carnitine HCl - 50mg

For Stress-Induced Memory Loss 

Currently, St. John’s Wort is most often used as a dietary supplement for depression. People also use it as a dietary supplement for other conditions, including menopausal symptoms, attention-deficit hyperactivity disorder (ADHD), and obsessive-compulsive disorder. It is used topically for wound healing. 

The flowering tops of St. John’s wort are used to prepare teas, tablets, capsules, and liquid extracts. Topical preparations are also available. There has been extensive research on St. John’s wort, especially on its use for depression and on its interactions with medications. 

Bacopa Leaf Extract - 120mg

For Memory Enhancing Support

Bacopa Monnieri is a adaptogen. Adaptogens are unique plants or herbs that support your adrenal system. Adaptogens enable the body to better cope with the deleterious mental and physical consequences of stress. This review synthesizes behavioral research with neuromolecular mechanisms putatively involved with the low-toxicity cognitive enhancing action of Bacopa monnieri (BM), a medicinal Ayurvedic herb. (Ayurveda is a system of medicine with historical roots in the Indian subcontinent) BM is traditionally used for various ailments, but is best known as a neural tonic and memory enhancer.

 

L-Glutamine - 150mg

Supports Concentration

L-glutamine is critical for an optimized brain. L-glutamine is a precursor to the neurotransmitter glutamate in your brain. The balance of glutamine and glutamate is crucial to an optimized and healthy brain. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells. Glutamine is a nonessential amino acid.

This agent is a substrate for the production of both excitatory and inhibitory neurotransmitters (glutamate and GABA) and is also an important source of energy for the nervous system. Glutamine may become a conditionally essential amino acid during certain catabolic states.

 

Alpha-GPC - 5mg

For Improved Focus

Alpha-glycerylphosphorylcholine (Alpha-GPC) and caffeine supplementation have been shown to improve mental and physical performance. Alpha-GPC administration increases the release of the neurotransmitter acetylcholine and facilitates learning and memory. In athletes, Alpha-GPC supplementation prevents exercise-induced reductions in choline levels, increases endurance performance and growth hormone secretion. Caffeine has been shown to increase mental focus, acuity and athletic performance, however, contributes to a nervous or anxious feeling. The purpose of this study was to measure the acute effects of Alpha-GPC supplementation in comparison to caffeine or placebo on mood, cognitive function, and physiological performance.

 

St. Johns Wort - 250mg

For Stress-Induced Memory Loss 

Currently, St. John’s Wort is most often used as a dietary supplement for depression. People also use it as a dietary supplement for other conditions, including menopausal symptoms, attention-deficit hyperactivity disorder (ADHD), and obsessive-compulsive disorder. It is used topically for wound healing. 

The flowering tops of St. John’s wort are used to prepare teas, tablets, capsules, and liquid extracts. Topical preparations are also available.There has been extensive research on St. John’s wort, especially on its use for depression and on its interactions with medications

Huperzine - A - 10mcg

For Cognition Support

Huperzine (HOOP-ur-zeen) A, a dietary supplement derived from the Chinese club moss Huperzia serrata, is sparking some interest as a potential treatment for Alzheimer’s disease. Huperzine A acts as a cholinesterase inhibitor — a type of medication that works by improving the levels of neurotransmitters in the brain. Small early studies suggest that Huperzine-A might improve memory and protect nerve cells, which could slow the cognitive decline associated with Alzheimer’s. Some studies have found evidence that Huperzine-A might significantly improve cognitive performance in people with Alzheimer’s disease. 

 

Allergen & Caution

ALLERGEN WARNING: CONTAINS SOY.

CAUTION: Do not exceed recommended dose. This product is not intended for pregnant or nursing mothers or children under 18. St. John’s Wort may contribute to photosensitivity resulting in skin irritation and redness in persons exposed to strong sunlight or tanning booths. Avoid use in patients at risk of bleeding, taking anticoagulants, or with clotting disorders, based on case reports of bleeding. Discontinue use 2-3 weeks prior to some surgical and dental procedures due to increased risk of bleeding. Avoid use in couples who are trying to conceive, based on theoretical reduction of fertility. If you have a history of seizures, are taking MAO inhibiting drugs, or if you have a known medical condition, consult a physician before using this or any dietary supplement. This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.

 

Continuing Care & MAINTANENCE

RenuFocus™ - Premium Nootropic Supplement

VEJOVIS 365 MULTIVITAMIN | RENUFOCUS NOOTRPIC | VEJOVIS STRESS GUMMIES

RenuFocus™ The Smart Pill

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